Basal Cell Carcinoma

Basal cell carcinoma (BCC) is the most common type of skin cancer. It starts in the top layer of the skin called the epidermis. Most BCCs show up on sun-exposed areas of the body, especially the face and neck. But they can occur in other areas too. BCC is often found early and can be cured. But sometimes it can grow back, and rarely it can spread to other parts of the body.

Fortunately, most BCCs are found early and cured. Still, it is very important to pay attention to sun safety. Here are some tips to make sure you and your family are staying safe:

  • Avoid being in the sun during peak daylight hours.
  • Always apply (and reapply) sunscreen.
  • Wear protective clothing, sunglasses, and wide-brimmed hats.
  • Talk to your family and friends about the importance of skin cancer prevention.
  • See your dermatologist regularly for skin exams.
  • Pay close attention to any sores or bumps that might develop on your skin.
  • Try to do regular skin self-exams. Make a date with your partner to check areas you can’t see like your back, scalp back of your legs or buttocks.

Often, you first notice BCC as a lesion on the skin that you think should heal in a week or two. However, one month later it is still there, getting red, raw, and irritated. If lesions do not resolve on their own, they need to be examined by a board-certified dermatologist.

Quick Guide to Advanced Non-Melanoma Skin Cancers

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What is Non-Melanoma Skin Cancer?

Ruby, your virtual community navigator, will help explain what you need to know about advanced Non-Melanoma Skin Cancer.

What is Advanced Basal Cell Carcinoma?

Ruby, your virtual community navigator, will help explain what you need to know about advanced Basal Cell Skin Cancer.

Risk Factors

Certain people are more likely to have basal cell carcinoma (BCC). Some risk factors include:

  • Spending too much time in the sun (especially without protection) or using tanning beds 
  • Frequent sunburns (especially at an early age) 
  • Fair skin, blond or red hair, and light-colored eyes 
  • Exposure to industrial compounds (radiation, coal tar, arsenic, other industrial compounds) 
  • A personal history or previous BCC or other skin cancer
  • Family history of skin cancer 
  • Certain medical conditions or medications (mostly conditions and medications that suppress your immune system) 
  • Radiation therapy 

Very rarely, people can have genetic syndromes where they develop numerous BCCs (>25). The most well-known is called basal cell carcinoma nevus syndrome (BCCNS). 

Signs & Symptoms

Basal cell carcinoma (BCC) will look and feel different. The appearance depends on the type it is. There are 6 types: superficial, pigmented, nodular, micronodular, infiltrative, or morpheaform.

Often, you first notice BCC as a lesion on the skin that you think should heal in a week or two. However, one month later it is still there, getting red, raw, and irritated. If lesions do not resolve on their own, they need to be examined by a board-certified dermatologist.

It might appear as a:

  • Smooth, shiny, pearly, or waxy bump
  • Firm red or flesh-colored bump that grows slowly and may bleed
  • Growth with unusual blood vessels in and around it
  • Sore that might bleed and doesn’t seem to be healing
  • Flat spot or patch of skin (usually red or brown) that is rough, dry, or scaly 
  • Area of scar-like tissue with no previous procedure done at the site
  • Moles that have an uneven shape or surrounding border

For people of color, BCC may appear as a darker bump, whereas in people with lighter skin tones, BCC may appear more translucent.  

Regardless of what it looks like, if you notice something on your skin that worries you, or if an existing growth starts to change or irritate you, get it checked out. Try to do regular skin exams, too. Getting comfortable with the look and feel of your skin will help you know what is normal and what’s not.

Spotlight on Skin Cancer: Advanced SCC and BSSC Skin Cancers

In this episode of our special series Spotlight on Skin Cancer, we take a look at 2 forms of advanced skin cancer: advanced basal and squamous cell skin cancers.

Screening, Diagnosis & Staging

You know your body best. Check your skin and discuss any changes with your doctor. Your doctor will complete a medical history that will include:

  • Your past exposure to the sun
  • Any exposure to other known causes of skin cancer
  • Your personal or family history of skin conditions
  • When you first noticed the mark
  • If the mark has changed at all in size or appearance


Tests that are commonly used to find skin cancer include:

Skin exams A dermatologist (or skin doctor) will check the skin for bumps or spots that look abnormal in color, size, shape, or texture.

Skin biopsy – A biopsy is typically needed to confirm a diagnosis of skin cancer. A biopsy is a common procedure to remove a part of an abnormal-looking growth. The area will be numbed with a local anesthetic injected into the skin. A different doctor (called a pathologist, often a dermatopathologist) will look at this tissue under the microscope to check for cancer cells. There are different types of biopsies that may be used depending on the cancer and its location.

If the disease is more advanced, other diagnostic tests may be added. However, this is done very infrequently.

On rare occasions, a person’s lymph node(s) may be removed to find out if the cancer has spread, which is called metastasis. The doctor may order other tests such as blood tests, chest x-rays, and imaging scans of the lymph nodes and nerves, liver, bones, and brain, but this is rare.

Basal cell carcinoma (BCC) has 3 main categories: low-risk, high-risk, and advanced. Low-risk BCC has a low chance of recurring, whereas high-risk BCC has a greater chance of coming back or recurring. This risk is measured by location, size, and symptoms of the BCC. Advanced BCC is BCC that has spread or metastasized.

Treatment Options and Side Effects

In most cases, basal cell carcinoma is easily cured using local surgery or medications applied to the skin (called topical therapies). Rarely, radiation can be used. Treatment will depend on where it is located, how big and deep the tumor is in the skin, and if local lymph nodes are involved. Additional treatment options are available for people with later-stage disease.



There are several different types of surgical procedures that can be used to remove tissue:

  • Excision – The entire growth is removed along with a surrounding border of normal skin.
  • Curettage and electrodesiccation – The tumor is scraped down to its base followed by pulses of electrical energy.
  • Mohs surgery – The goal is to remove skin cancer one layer at a time to spare normal, healthy tissue. After each layer is removed, it is sent to an on-site laboratory to be examined by the surgeon. This allows your dermatologic surgeon to know whether more layers need to be removed in real-time.
  • Cryosurgery – The tumor is frozen off using a cold substance like liquid nitrogen.

Basal cell carcinoma can invade nearby tissue. If this happens, more tissue will need to be removed, leading to larger scars that some people may find upsetting. That's why it is important to get things checked out early. When found early, they are usually much easier to remove and your surgery site will be smaller.

Possible side effects of surgery may include:

  • Pain
  • Scarring
  • Numbness
  • Skin stretching
  • Wound problems
  • Infection
  • Changes in appearance where the surgery was performed


Medications for the Skin

If BCC is “superficial” (in other words, not very deep in the skin), creams containing medications (imiquimod or 5-florouracil) can be applied to the skin.

The following side effects are common:

  • Pain
  • Itching
  • Burning
  • Irritation
  • Inflammation
  • Dryness
  • Swelling
  • Tenderness at the site of application. This will heal once the treatment is complete.


Radiation Therapy

Radiation is most often used in patients who cannot undergo surgery for one reason or another. It may also be used in patients who have BCC that has spread to lymph nodes. It may not be recommended for people with BCCNS because they are at higher risk of forming numerous new skin cancers after radiation exposure.

Learn more about radiation therapy


Systemic Treatments

For patients who have had extensive surgeries and can no longer undergo any more procedures because of how advanced the disease is locally and patients with stage IV disease, where the primary tumor is a certain size and can involve local lymph nodes and, rarely, distant metastasis (most often lungs, bones, and liver), other treatments such as (intravenous) chemotherapy, targeted therapy (that work to block signals that tell cancer to grow in certain people), palliative care (to help with physical and emotional symptoms), immunotherapy, and clinical trials may be available.


Receiving a cancer diagnosis and going through cancer treatment can be challenging for both patients and their caregivers. It is important that patients work with their care teams to make treatment decisions that best support the patient’s needs and goals. For patients with BCC, their care team may include many different types of doctors. It can be helpful to plan ahead for visits with different specialists.

Patients can prepare by:

  • Maintaining a list of all members of the care team and their contact information
  • Writing a list of symptoms, side effects, and questions
  • Accessing resources and information specific to their diagnosis
  • Talking with their loved ones about the support that they need

Side effects of cancer treatment can intensify challenges. Patients and caregivers can work with their care teams to better understand potential side effects. Know that there are steps patients, caregivers, and the health care team can take to help improve the mental and physical well-being.

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